IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic analogue of the naturally occurring hormone IGF-1, primarily used in laboratory research for its enhanced stability and potent anabolic properties. It is not approved for human consumption or therapeutic use outside specific medical conditions and research settings.
Description and Mechanism
IGF-1 LR3 is a modified protein consisting of 83 amino acids, which includes an extra 13 amino acids at its N-terminus and a substitution of arginine for glutamic acid at the third position.
These structural changes give it a significantly longer half-life of 20-30 hours compared to native IGF-1, which only lasts minutes in circulation.
Its primary mechanism involves:
- Binding to receptors: It binds to IGF-1 receptors (IGF-1R) on cell surfaces, activating intracellular signaling pathways that promote cell growth, proliferation, and survival.
- Reduced binding protein affinity: The modifications allow it to largely bypass the IGF-binding proteins (IGFBPs) that typically regulate and inhibit native IGF-1 activity, allowing for more widespread and sustained systemic effects.
- Nutrient metabolism: It increases the uptake of glucose and amino acids into muscle cells, enhancing protein synthesis and facilitating fat burning for energy.
For research use only, not to be used in clinical trials involving humans. Documentation is for information only.
Note:
With this option, we will mix it for you with bacteriostatic water and put it into a disposable pen (no vial received). The pen offers easy and accurate dosing for your research purposes, adjustable from 1 to 60 iu’s. It comes complete with enough alcohol swabs and needles to complete your research, all contained in a case.
If you already have a reusable pen you can also buy this peptide premixed in a cartridge only (see alternate product).