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Key Functions & Benefits
- Origin: Encoded by the mitochondrial genome (16S ribosomal RNA gene, MT-RNR2).
- Neuroprotection: It was initially identified for its ability to protect neurons from amyloid-beta induced cell death (Alzheimer’s).
- Disease Resistance: Humanin acts as a stress-response molecule that is protective against Alzheimer’s, strokes, atherosclerosis, and myocardial infarction.
- Metabolic Effects: It improves glucose metabolism and insulin sensitivity in animal models, showing potential in treating obesity and type 2 diabetes.
- Aging & Lifespan: Levels of humanin in the blood correlate with lifespan in various mouse models, and its levels are higher in the children of supercentenarians.
- Signaling Mechanism: Humanin acts through the GP130/1L6ST receptor complex to activate protective pathways like AKT,, ERK1/2 and STAT3.
